The adventure of the speckled band.
It grew louder and louder, a hoarse shout of pain and fear and anger all mixed in the one dreadful scream. They say that away down in the village, and even further away than that, that cry raised sleeping people from their beds. It struck a cold feeling into our hearts, and I stood looking at Holmes, and he at me, until the last echoes of it had died away into the silence.
"What can it mean?" I asked.
"It means that it is all over," Holmes answered. "And perhaps, after all, it is the best thing that could have happened. Take your pistol, and we will enter Dr. Roylott's room."