The adventure of the speckled band
It grew louder and louder. There was pain and fear and anger all mixed up in it. The scream was so loud that it woke up people in the village, and even further away than that. The horrible scream left a cold feeling in our hearts. I stood looking at Holmes, and Holmes looked at me, until there was silence again.
"What can that scream be for?" I asked.
"It means that it is finished," Holmes answered. "And perhaps, it is the best thing that could have happened. Take your pistol. We will go to Dr. Roylott's room."